8-Amino guanine accelerates tetramolecular G-quadruplex formation.
نویسندگان
چکیده
We demonstrate here that 8-amino guanine () strongly accelerates quadruplex formation, which makes this nucleobase the most attractive replacement for guanine in the context of tetramolecular parallel quadruplexes.
منابع مشابه
8-Amino guanine accelerates tetramolecular G-quadruplex formationwz
G-Quadruplexes are a family of four-stranded DNA structures stabilized by guanine quartets. These structures have a low tolerance for non-guanine quartets which are rather formed by virtue of the docking platform provided by neighboring G-quartets. Few exceptions have been found. We demonstrate here that 8-amino guanine (R, Fig. 1) strongly accelerates quadruplex formation, which makes this nuc...
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عنوان ژورنال:
- Chemical communications
دوره 25 شماره
صفحات -
تاریخ انتشار 2008